What is LysoPhar-HQ?

Lysophar-HQ is the name of the pharmaceutical grade lysozyme from Bouwhuis Enthoven. Lysozyme is one of the proteins in egg albumen. The function in the egg albumen is to protect the unborn chicken against certain microbiological infections. Lysozyme can be found in many sources, but the amount of lysozyme in hen egg white is the highest, and therefore it is commercially feasible to extract lysozyme from egg white.It was first discovered by Alexander Fleming in 1922, and identified in egg white in 1945.

Property Value
Molecular weight 14.400
Amino acids 129
pI 10,7
Synonyms Murimidase, N-acetylmuramic-hydrolase
Classification E.C.3.2.17
C.A.S. Number 9066059-5
Einecs 232-620-4
EC Regulation 1333/2008 E1105

unique advantages

Compared to other suppliers of pharmaceutical lysozyme, LysoPhar-HQ has some unique advantages:

  1. Reliability and continuity in supply. We have our own production facility for lysozyme in direct connection with egg  production, breaking , separating and extracting. Each batch of product produced is subject to a quality review covering retrospective validation of all- in-process controls.
  2. Fully traceable. Eggs used for the production of LysoPhar-HQ are from contracted farms in the Netherlands, Germany and Belgium. The feed used for the laying hens, the history of the laying hens and all further details are known and recorded.
  3. Investment. Early 2014 investment was made in the latest drying technologies for lysozyme and in high-end filling equipment in a clean room environment.
  4. Tailor-made production opportunities based on specific requests of our customers.
  5. Bouwhuis-Enthoven. We have a long-standing experience in producing lysozyme and are a well-known global brand in the food application of lysozyme.


Regulatory issues.

The Japanese Pharmacopee has published a monograph for lysozyme, which acts as a world-wide reference. Lysozyme from Bouwhuis Enthoven meets the requirements as laid down in this monograph. Bouwhuis Enthoven is registered as an API manufacturer with Farmatec (the official governmental organisation in the Netherlands) under nr. 6083 API.

A GMP inspection by the Dutch Health Authorities (IGZ) has been carried out and a Certificate of GMP Compliance has been issued. Next to this, the company is audited on an annual basis by SGS against the ICH Guidelines covering Good Manufacturing Practices for Active Pharmaceutical Ingredients Q7 and a certificate of compliance has been issued.



What is the use of lysozyme in pharma?

Lysozyme can be regarded as an Active Pharmaceutical Ingredient. Most of the applications are OTC products. The main pharmaceutical use of lysozyme is in nasal and throat preparations. Other applications include use as an anti-bacterial (against bacterial or viral inflammatory diseases), in aerosols for the treatment of bronchopulmonary diseases. Also prophylactically for dental caries, and in creams for protection against topical reparation of certain dystrophic and inflammatory lesions of the skin and soft tissues. A full list of applications of LysoPhar-HQ is available upon request. Apart from the pharmaceutical application of lysozyme, the product is used in the preservation of mainly fermented food products, like cheese and wine.

How is LysoPhar-HQ produced?

Lysozyme is extracted from egg white by ion-exchange. Subsequently, the pH is set at iso-electric point; the precipitate is washed to remove adhering non-lysozyme proteins. By lowering the pH, the precipitate is dissolved. Following, this it is purified by centrifugation and filtration, concentrated, pasteurised by thermal treatment and dried.

Who is Bouwhuis Enthoven?

Bouwhuis Enthoven is a producer of liquid and dried egg products in the Netherlands. Our products serve mainly as ingredients in the food industry. Bouwhuis Enthoven (www.bouwhuis-enthoven.com) is part of the Van Beek Group (www.vanbeekgroup.nl), a leading family-owned company in the field of egg and egg products.

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